Numab delivered a poster presentation today, providing new animal data on its lead I/O drug candidate, NM21-1480, emerging from the company’s ND021 program. NM21-1480 is a PD-L1/4-1BB/HSA trispecific scMATCH3 that simultaneously blocks PD-(L)1 signaling and conditionally costimulates 4-1BB+ cells in the tumor microenvironment. The unique properties of NM21-1480 enables best-in-class antitumoral efficacy while avoiding extratumoral activity and thereby preventing any 4-1BB-mediated toxicities. Studies in mice and non-human primates support NM21-1480 as a safe and highly effective drug candidate for a variety of cancers.
Please click here to view the poster.